大剂量静脉注射丙种球蛋白治疗自身免疫性血小板减少症有效,能迅速提高血小板数和减少出血,没有副作用。此法适用于治疗有急性出血倾向的病人,但价格昂贵。静脉注射丙种球蛋白的作用机理是暂时抑制巨噬细胞(IgGFc 受体部位)对自身抗体介导的血小板破坏。糖皮质激素也是抑制巨噬细胞对自身抗体敏感血小板的破坏。治疗器官移植排斥反应的经验表明,大剂量静脉注射糖皮质激素是迅速有效的,如仅给药几天,也没有严重的副作用,且不像丙种球蛋 High-dose intravenous gamma globulin treatment of autoimmune thrombocytopenia effective, can rapidly increase the number of platelets and reduce bleeding, no side effects. This method is suitable for the treatment of patients with acute bleeding tendency, but expensive. The mechanism of action of intravenous gamma globulin is to temporarily inhibit autoantibody-mediated platelet destruction by macrophages (IgGFc receptor sites). Glucocorticoids also inhibit the destruction of autoantibodies to platelets by macrophages. Experience with organ transplant rejection has shown that high-dose intravenous glucocorticoids are rapid and effective, administered for days, without serious side effects, and unlike gamma globulin