吗丁啉(多潘立酮)具有外周阻滞作用,是作用较强的多巴胺受体拮抗剂,为一种新型胃动力型药物,对非溃疡性消化不良疗效较好,已广泛用于临床.但由于其不易透过血脑屏障,几乎无锥体外系的副作用,使其安全系数大大高于胃复安,但我院于1991年曾发现1例因口服吗丁啉引起锥体外系综合症的患者,报告如下. Domperidone (domperidone) with peripheral block, is a strong dopamine receptor antagonist, is a new type of gastric motility drug, non-ulcer dyspepsia better efficacy, has been widely used in clinical.But due to Its not easy to penetrate the blood-brain barrier, almost no extrapyramidal side effects, the safety factor is much higher than metoclopramide, but our hospital in 1991 found 1 cases of patients with extrapyramidal constipation caused by oral morphine , The report is as follows.