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现已发现具有致突变作用的化合物和引起实验动物发生恶性肿瘤之间有着密切关系,认为这二种过程有共同的分子机制,故短期致突变试验可用来予报致癌的危险性。已报道Ames试验予报的价值为90%,但Ames试验只能反映点突变的情况。目前微核试验作为快速筛选环境中遗传有害物质的一种方法已为人们所注视。它不仅反映了染色体畸变和不离开,而且反映了哺乳动物的体内状态,也适用于人体的研究。
It has been found that there is a close relationship between compounds that have mutagenic effects and the development of malignant tumors in experimental animals. We believe that these two processes have a common molecular mechanism, so short-term mutagenicity test can be used to report the risk of cancer. Ames test has reportedly reported a value of 90%, but the Ames test only reflects the case of point mutations. Micronucleus test is currently used as a method of rapid screening of genetic harmful substances in the environment. It not only reflects the chromosome aberrations and does not leave, but also reflects the mammalian in vivo state, but also for human research.