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目的:观察并探讨用多潘立酮联合铝碳酸镁治疗胆汁反流性胃炎的临床效果。方法:对2009年2月～2012年2月期间我院收治的130例胆汁反流性胃炎患者的临床资料进行回顾性研究。我们采用随机数字表法将这130例患者分为对照组和联合组,每组各有65例患者。其中,对照组患者单独使用多潘立酮进行治疗,联合组患者在使用多潘立酮的基础上,加用铝碳酸镁进行治疗。两组患者治疗的疗程均为2个月。治疗结束后,比较两组患者治疗的有效率,同时将两组患者治疗24小时后胆汁反流的检测指标和治疗前后临床症状的积分情况进行对比。结果:联合组患者治疗的有效率明显高于对照组患者,二者相比差异具有显著性(p<0.05)。对照组患者与联合组患者治疗后临床症状的积分均明显低于治疗前,同时,联合组患者临床症状的积分明显低于对照组患者,二者相比差异具有显著性(p<0.05)。联合组患者治疗24小时后胆汁反流时间的百分比、反流的次数、反流时间大于5分钟的反流次数均少于对照组患者,二者相比差异具有显著性(p<0.05)。结论:用多潘立酮联合铝碳酸镁治疗胆汁反流性胃炎效果确切,能够有效地改善患者的临床症状,减少其胆汁反流的时间和次数,具有临床使用价值。
Objective: To observe and discuss the clinical effects of domperidone and magnesium aluminum carbonate in the treatment of bile reflux gastritis. Methods: The clinical data of 130 patients with bile reflux gastritis admitted to our hospital from February 2009 to February 2012 were retrospectively studied. We used random number table method these 130 patients were divided into control group and the combined group, each with 65 patients. Among them, the control group of patients treated with domperidone alone, the combined group of patients on the basis of the use of domperidone plus magnesium aluminum carbonate for treatment. Two groups of patients treated for 2 months. After treatment, the efficiency of treatment was compared between the two groups. At the same time, the detection indexes of bile reflux after 24 hours of treatment were compared with those of clinical symptoms before and after treatment. Results: The effective rate of treatment in combination group was significantly higher than that in control group, the difference was significant (p <0.05). The scores of clinical symptoms of patients in the control group and the combination group were significantly lower than those before treatment. Meanwhile, the scores of clinical symptoms in the combination group were significantly lower than those in the control group (p <0.05). The percentage of bile reflux time, the number of reflux, the number of reflux times more than 5 minutes after the treatment in the combined group were less than those in the control group after 24 hours of treatment, the difference was significant (p <0.05). Conclusion: The treatment of bile reflux gastritis with domperidone and magnesium aluminum carbonate has the exact effect, which can effectively improve the clinical symptoms and reduce the time and frequency of bile reflux, and has clinical value.