乌头、附子皆为毛莨科植物的块根或子根，古今药典一致认为有大毒。从现代药理研究可以看出，乌头、附子的主要有毒成份为乌头碱类化合物，其中又以脂键的存在最为关键。原药用传统法加工炮制以后，可使脂键充分水解而毒性降低，处方用药时须注明先煎60～120分钟，并加大甘草配 Aconitum and Aconite are all the roots or subroots of Ranunculaceae. The ancient and modern pharmacopoeia unanimously believed that there were big poisons. From modern pharmacological studies, it can be seen that the main toxic components of Aconitum and Aconitum are aconitine compounds, and the presence of lipid bonds is the most critical. After the crude drug is processed by the traditional method, the lipid bond can be fully hydrolyzed and the toxicity is reduced. When prescribing the drug, it is necessary to indicate the first frying for 60 to 120 minutes, and increase the licorice