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雷公藤(Tripterygium Wilfordii Hook.F)系卫矛科雷公藤属植物,临床用于治疗类风湿性关节炎等疾病,疗效肯定。以雷公藤的乙酸乙酯提取物制成的雷公藤片已投产。工艺为: 雷公藤全根乙醇提取醇浸膏加水水层乙酸乙酯提取乙酸乙酯浸膏加辅料压片此外,以雷公藤根皮为原料、提取分离得到的雷公藤内酯醇(triptolide)配成0.002％的软膏(雷酯醇软膏),外用可治疗银屑病,也已投入生产。工艺为: 雷公藤根皮乙醇提取醇浸膏加水水层氯仿提取氯仿浸膏柱层析分离雷公藤内酯醇加基质软膏上述两种的雷公藤醇浸膏加水后,产生大量的胶状沉淀(约占生药量的10％),一般都作为废渣弃去。我们对沉淀物进行分析发现其中含有较大量的生物碱类成分。药理实验表明,雷公藤总碱有雄性抗生育活性,其作用与棉酚有很多相似之处,有希望成为一种新的男性避孕
Tripterygium Wilfordii Hook.F is a plant belonging to the genus Euonymus, which is used clinically to treat diseases such as rheumatoid arthritis. Triptolide tablets made from ethyl acetate extract of Tripterygium wilfordii have been put into production. The process is as follows: Tripterygium wilfordii ethanol extract and aqueous extract ethyl acetate extract Ethyl acetate extract and auxiliary tableting In addition, triptolide is extracted and separated from Tripterygium wilfordii root cane as raw material. 0.002% ointment (Lactylol ointment), which can be used externally to treat psoriasis, has also been put into production. The process is as follows: Tripterygium wilfordii ethanol extract alcohol extract plus aqueous layer chloroform extraction chloroform extraction column chromatography chromatographic separation of triptolide alcohol plus matrix ointment After the above two kinds of Tripterygium wilfordii extract add water, produce a large amount of gelatinous precipitate (about 10% of the raw drug amount is generally discarded as waste residue. We analyzed the sediment and found that it contains a large amount of alkaloids. Pharmacological experiments have shown that the total alkaloids of Tripterygium wilfordii have male antifertility activity, and its effects have many similarities with gossypol, promising to become a new male contraceptive