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本文通过1次和多次给小鼠不同剂量的亚硒酸钠,以~3H-TdR掺入脾细胞DNA为指标,同时进行全血硒浓度测定,观察了补硒对小鼠体内细胞DNA合成的影响以及与血硒浓度的关系。结果表明:①亚硒酸钠对脾细胞DNA合成呈双相作用,低剂量促进其合成,高剂量则产生毒性抑制作用,毒性作用短暂、可逆,与1次大剂量有关。②多次给硒,最终血硒浓度与毒性作用之间不呈正相关。③补硒的单次剂量和方式影响稳态血硒浓度水平。
In this paper, one and several times to mice with different doses of sodium selenite, ~ 3H-TdR incorporation of DNA into spleen cells as an indicator, at the same time selenium concentration determination was observed selenium in mice cells in vivo DNA synthesis The impact and the relationship between blood selenium concentration. The results showed that: (1) Sodium selenite had a biphasic effect on DNA synthesis of spleen cells. Low dose of sodium selenite could promote its synthesis, while high dose of sodium selenite produced toxic inhibition. The toxicity was transient and reversible, which was related to a large dose. ② repeatedly to selenium, the final concentration of selenium and toxic effects are not positively correlated. ③ a single dose of selenium and the way the steady-state blood selenium concentration levels.