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目的探讨超敏C-反应蛋白(hs-CRP)在7种常见肾脏病中的变化。方法通过对近半年来就诊的治疗前的血肌酐正常的狼疮性肾炎(LN1)、紫癜性肾炎(PN)、慢性肾炎(CGN1)、原发性肾病综合征(PNS1),血肌酐升高的糖尿病肾病(DN)、非尿毒症期的慢性肾炎(CRF1)、尿毒症期的慢性肾炎(CRF2)患者和治疗后尿蛋白转阴、血肌酐正常的狼疮性肾炎(LN2)、慢性肾炎(CGN2)、原发性肾病综合征(PNS2)患者及健康体检人群的hs-CRP的测定,总结hs-CRP的变化规律。结果治疗前与正常人群比较,LN1、PN、CGN1、PNS1、CRF1、CRF2和DN组患者CRP水平增高(P<0.05);与CGN1和PNS1组患者比较,LN1和CRF2组患者CRP水平显著升高(P<0.05);DN、CRF1和CRF2组3组间患者CRP水平无统计学意义(P>0.05);CGN1和PNS1组2组间患者CRP水平无统计学意义(P>0.05)。治疗后与正常人群比较,LN2组患者CRP水平仍显著升高(P<0.05),CGN2和PNS2组患者CRP水平无统计学意义(P>0.05);LN2、PNS2组患者CRP水平较治疗前显著降低(P<0.05),CGN2组患者CRP水平较治疗前无统计学意义(P>0.05)。结论在狼疮性肾炎、紫癜性肾炎等7种常见肾脏病中hs-CRP水平较正常人群升高,不同肾脏病的hs-CRP水平还存在差异,尿蛋白转阴并不一定代表炎症反应得到了控制,积极控制炎症反应,可能对预防心脑血管事件的发生具有重要意义。
Objective To investigate the changes of hs-CRP in 7 common kidney diseases. Methods The serum creatinine (LN1), purpuric nephritis (PN), chronic nephritis (CGN1), primary nephrotic syndrome (PNS1), elevated serum creatinine Diabetic nephropathy (DN), non-uremic chronic nephritis (CRF1), uremic chronic nephritis (CRF2) and post-treatment urinary protein negative, serum creatinine normal lupus nephritis (LN2), chronic nephritis ), Hs-CRP in patients with primary nephrotic syndrome (PNS2) and healthy people, and summarize the changes of hs-CRP. Results The CRP levels in LN1, PN, CGN1, PNS1, CRF1, CRF2 and DN groups were significantly higher than those in normal controls before treatment (P <0.05). CRP levels in LN1 and CRF2 group were significantly higher than those in CGN1 and PNS1 group (P <0.05). CRP levels in DN, CRF1 and CRF2 groups were not statistically significant (P> 0.05). There was no significant difference in CRP levels between CGN1 and PNS1 groups (P> 0.05). After treatment, CRP levels in LN2 group were still significantly higher than those in normal group (P <0.05), CRN levels in CGN2 and PNS2 group were not statistically significant (P> 0.05); CRP levels in LN2 and PNS2 group were significantly higher than those before treatment (P <0.05). There was no significant difference in CRP level between CGN2 group and before treatment (P> 0.05). Conclusions The levels of hs-CRP in seven common kidney diseases such as lupus nephritis and purpuric nephritis are higher than those in normal people. There are also differences in the levels of hs-CRP between different kidney diseases. Urine protein negative does not necessarily mean that the inflammatory response is obtained Control, and actively control the inflammatory response, may play an important role in the prevention of cardiovascular and cerebrovascular events.