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对西安市某医院 86例门诊和住院慢性乙型肝炎患者进行 α-干扰素加Vit E联合治疗的疗效观察。结果 :实验组与对照组相比 ,其总有效率分别为 88.6 %和 6 1 .9% ( P <0 .0 1 ) ;肝功能复常率为 88.6 %和 5 7.1 % ( P <0 .0 1 )。治疗结束时 ,两组 HBe Ag阴转率分别是 5 0 .0 %和 2 8.6 % ;HBV- DNA阴转率为 6 8.4%和35 .3%。治疗结束后 6个月 HBe Ag阴转率分别为 5 6 .8%和 31 .0 % ;HBV- DNA阴转率是 6 8.4%和 38.2 %。表明 α-干扰素加 Vit E治疗慢性乙肝无论其暂时效果或持续效应 ,实验组均明显高于对照组 ( P <0 .0 5 )
To observe the curative effect of combined treatment of α-interferon and Vit E on 86 outpatients and inpatients with chronic hepatitis B in a hospital in Xi’an. Results: Compared with the control group, the total effective rate was 88.6% and 61.9% (P <0. 01) respectively. The rate of normalization of liver function was 88.6% and 51.1% (P <0. 0 1). At the end of treatment, the negative conversion rates of HBe Ag in both groups were 50.0% and 22.6%, respectively, and the negative conversion rates of HBV DNA were 6 8.4% and 35.3%. The negative conversion rate of HBe Ag was 56.8% and 31.0% at 6 months after treatment, and the negative conversion rates of HBV DNA were 6 8.4% and 38.2%. The results showed that α-interferon and Vit E treatment of chronic hepatitis B, regardless of their temporary effect or sustained effect, the experimental group were significantly higher than the control group (P <0 05)