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应用2×2析因实验设计将 Wistar 大鼠随机分为四组:I~+Se~+组,I~+Se~-组,I~-Se~+组。I~-Se~-组。采用辣根过氧化物酶(HRP)示踪技术观察了喂养30周大鼠甲状腺细胞膜通透性变化。结果表明,缺碘组(I~-Se~+和 I~-Se~-)含 HRP 反应产物细胞的数密度明显高于补碘组(I~+Se~+和 I~+Se~-),缺硒也有此作用,但其作用效果远不如缺碘的作用显著,而主要表观在缺碘的条件下,缺硒可使含反应产物细胞数量明显增多,但在碘正常情况下缺硒的影响则不明显。提示缺碘是造成甲状腺细胞损伤而膜通透性增大的主要原因,在缺碘条件下缺硒可加重细胞损伤。
Wistar rats were randomly divided into four groups: I ~ + Se ~ + group, I ~ + Se ~ - group, I ~ -Se ~ + group by 2 × 2 factorial experimental design. I ~ -Se ~ - group. The changes of membrane permeability of thyrocytes in 30-week-old rats were observed by horseradish peroxidase (HRP) tracer technique. The results showed that the number densities of cells containing HRP in I ~ -Se ~ + and I ~ -Se ~ - groups were significantly higher than those in Iodine-supplemented group (I ~ + Se ~ + and I ~ + Se ~ -) , Selenium also has this effect, but its role is far less effective than the role of iodine deficiency, while the main appearance of iodine deficiency conditions, the lack of selenium can significantly increase the number of cells containing reaction products, but in the case of iodine deficiency Se deficiency The impact is not obvious. Tip iodine deficiency is caused by thyroid cell damage and membrane permeability increases the main reason, in the absence of iodine deficiency selenium can aggravate cell damage.