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目的探讨药物Dimebon在阿尔茨海默氏病(AD)和亨廷顿氏病(HD)的药理作用。方法采用膜片钳技术在培养的小鼠纹状体中型多棘神经元(medium spiny striatal neurons,MSN)上观察不同浓度的Dimebon对NMDA(N-methyl-D-aspartic acid)受体激活电流的影响。结果高浓度的Dimebon抑制NMDA激活电流,而低浓度的Dimebon增强NMDA激活电流,从而下调NMDA受体。结论 Dimebon对NMDA受体激活电流的影响有双重作用,依Dimebon浓度的不同而不同,为临床用药提供依据。
Objective To investigate the pharmacological effects of Dimebon in Alzheimer’s disease (AD) and Huntington’s disease (HD). Methods Patch clamp technique was used to observe the effect of Dimebon on NMDA (N-methyl-D-aspartic acid) receptor activation current in cultured mouse splenic striatal neurons (MSN) influences. Results High concentrations of Dimebon inhibited NMDA activation currents, while low concentrations of Dimebon increased NMDA activation currents, thereby down-regulating NMDA receptors. Conclusion Dimebon has a dual effect on the NMDA receptor activation current, which may provide a basis for clinical use depending on the concentration of dimebon.