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本文对两个Huntington舞蹈病家系进行调查并应用PCR技术作了基因检测,所用引物为5’—CTGTGGGACCTCGGCTAAGC—3’及5’—GTCAGCACCTCAGACCAGAG—3’,合成了PYNZ—32标志基因。经多态性连锁分析提示它对国人Huntington舞蹈病进行基因检测和临床应用具有可能性。
In this paper, two Huntington chorea pedigrees were investigated and PCR technology was used to detect the gene. PYNZ-32 marker gene was synthesized using 5’-CTGTGGGACCTCGGCTAAGC-3 ’and 5’-GTCAGCACCTCAGACCAGAG-3’. Polymorphic linkage analysis showed that it is possible to carry out genetic testing and clinical application of Chinese Huntington chorea.