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CD147被称为细胞外基质金属蛋白酶（ MMPs）诱导因子，可诱导周围细胞表达并分泌MMPs，而MMPs可降解细胞外基质，两者共同参与肿瘤细胞之间、肿瘤细胞和基质细胞之间的相互作用，促进肿瘤的侵袭与转移。 MMPs家族中又以MMP－2、MMP－9与乳腺癌关系最为密切，故该文主要针对MMP－2、MMP－9及其诱导因子CD147在乳腺癌发生、发展中的作用以及以 CD147和 MMPs为靶点的抗肿瘤治疗的相关研究进展予以综述。“,”CD147 is known as extracellular matrix metalloproteinase inducer,which can induce the sur-rounding cells to express and secrete matrix metalloproteinases ( MMPs) ,while MMPs can degrade extracel-lular matrix.CD147 and MMPs together participate in the interaction between tumor cells, and tumor cells and stromal cells to promote tumor invasion and metastasis.In MMPs family,MMP-2 and MMP-9 are most closely related to breast cancer.Therefore,here is to make a review of the related research progress of MMP-2 and MMP-9 and their inducer CD147 in breast cancer and the cancer therapy targeted at CD147 and MMPs.