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目的调查我院重症医学科(ICU)院内感染的发病率、发病特点、病原菌分布及危险因素，以及研究相应的干预措施对ICU住院病人院内感染的影响。方法回顾性分析我院2010年2月-2011年1月(对照组)入住ICU的1843例患者院内感染情况及相关因素，并在2011年2月—2012年1月(干预组)给予针对性的干预措施，研究护理干预措施对院内感染的影响。结果对照组1843例患者中，发生院内感染206例，发病率11.18%。其中下呼吸道感染居第一位(69.90%)，以昏迷、有慢性肺病、留置胃管、气管切开以及使用呼吸机大于5天的病人为主；并且临床病情分类分值越高，院内感染发生率越高；干预组病人院内感染发生率为8.80%，与对照组相比差异具有统计学意义。通过给予相应的护理干预，总发病率、男性病人感染率、以及60岁以上患者感染率与对照组相比均明显下降。结论 对气管切开、昏迷、有慢性肺病、留置导管时间长且使用呼吸机的男性危重病人及时给与护理干预措施，是降低院内感染发病率的有效途径之一。“,”Objective: To investigate the risk factors, disease incidence, characteristic and the distribution of Pathogens of hospital acquired infection of the patients in ICU, and research the effects of nursing intervention on Hospital Acquired Infection. Methods :A retrospective analysis was made to investigate on the records of 1843 cases of patients in Feb.2010-Jan.2011 in ICU.At the same time, several nursing interventions were given to research the effects of nursing intervention on Hospital Acquired Infection in the period of Feb.2011-Jan.2012 . Results: The infection rate was 11.18%in the control group, the respiratory infections was the first place in hospital acquired infection for 69.90%.The frequent infection factors were coma、chronic pulmonary disease、gastric tube detaining、tracheotomy and ventilator using more than 5 days;the higher the value of clinical disease classification was one of the reasons. The infection rate in the intervention group was 8.80% By giving appropriate nursing interventions, the total infection rates , the infection rates in male patients and patients over the age of 60 were significantly decreased compared with the control group. Conclusion :Intensive nursing care is need for tracheotomy、coma、chronic pulmonary disease、ventilator using more days.