一、概述糖尿病心肌病(DC)最早是由Rubler等于1972提出的。DC的可能病因包括代谢紊乱、胰岛素抵抗(IR)、心脏小血管病变、心脏自主神经系统的紊乱、心肌纤维,凋亡及坏死等,其中IR在DC的发生发展过程中起重要作用,最终导致心肌细胞肥大、心肌间质纤维化、胶原沉积等病理变化。因此,DC的治疗可结合已有的有关DC的研究成果,并以其特 First, an overview Diabetic cardiomyopathy (DC) was first proposed by Rubler equal to 1972. Possible causes of DC include metabolic disorders, insulin resistance (IR), small heart disease, cardiac autonomic nervous system disorders, myocardial fibrosis, apoptosis and necrosis, among which IR plays an important role in the development and progression of DC, which eventually leads to Cardiomyocyte hypertrophy, myocardial interstitial fibrosis, collagen deposition and other pathological changes. Therefore, the treatment of DC can be combined with the existing research results on DC, and its special