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探讨十二指肠溃疡（DU）内血浆促胃动素（MTL)和β内啡肽（β-EP）的关系。方法：用放射免疫法测定活动期DU、疤痕期DU患者及健康对照组的血浆MTL和β－EP浓度，并进行比较分析。结果：活动期DU及疤痕期DU患者的血浆MTL浓度均明显低于正常对照组（活动期DU：153．79ng／L±42．20ng／L，疤痕期DU：154．96ng／L±46．32，g／L，正常对照组：190．49ng／L±36.54ng／L）。活动期DU患者的血浆β-EP浓度明显高于正常对照组，而疤痕期DU患者的血浆β-EP浓度与正常对照组无显著差异（活动期DU:12．56ng／L±4．62ng／L，疤痕期DU：9.11ng／L±4．09ng／L，正常对照组：8．92ng／L±3.45ng／L）。结论：DU患者的血浆MTL浓度降低和β-EP浓度升高可能参与DU发生、发展的病理生理过程。
To investigate the relationship between plasma motilin (β-EP) and endotoxin (β-EP) in duodenal ulcer (DU). Methods: Plasma MTL and β-EP concentrations in active DU, scar DU patients and healthy controls were determined by radioimmunoassay and compared. Results: The plasma concentrations of MTL in active DU and scar DU patients were significantly lower than those in normal controls (active DU: 153.79 ng / L ± 42.20 ng / L, scar: DU: 154.96 ng / L ± 46). 32, g / L, normal control group: 190.49ng / L ± 36.54ng / L). The plasma β-EP concentration in patients with active DU was significantly higher than that in the normal control group, while there was no significant difference between the plasma levels of β-EP and the normal control group in active DU patients (active DU: 12.56ng / L ± 4.62ng / L, scar stage DU: 9.11ng / L ± 4.09ng / L, normal control group: 8.92ng / L ± 3.45ng / L). Conclusion: The decrease of plasma MTL concentration and the increase of β-EP concentration in DU patients may be involved in the pathogenesis of DU.