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目的探讨血清VEGF、TNF-α、IL-1β、CA125联合检测在子宫内膜异位症诊断中的应用价值。方法选取2015年5月-2017年3月在湖南省妇幼保健院接受治疗的子宫内膜异位症患者为研究对象,并作为观察组。同时选取80例健康者作为对照组,比较两组患者之间及观察组不同疾病分期患者的血清中VEGF、TNF-α、IL-1β、CA125水平的差异,分析子宫内膜异位症患者CA125水平与VEGF、TNF-α、IL-1β水平的相关性。结果观察组患者血清VEGF、TNF-α、IL-1β和CA125水平明显高于对照组(t=-36.588、-45.027、-26.487、-111.105,P<0.001);Ⅲ~Ⅳ期子宫内膜异位症组患者的血清VEGF、TNF-α、IL-1β和CA125水平明显高于Ⅰ-Ⅱ期子宫内膜异位症组(t=-38.815、-7.697、-9.905、-21.326,P<0.001);子宫内膜异位症患者血清CA125水平与VEGF、TNF-α、IL-1β水平明显正相关(r=0.489、0.512、0.538,P=0.023、0.015、0.002);CA125对子宫内膜异位症诊断特异度和灵敏度分别为45.63、35.18,CA125联合VEGF、TNF-α、IL-1β对子宫内膜异位症诊断特异度和灵敏度较高,分别为65.32、55.86。结论子宫内膜异位症患者的血清VEGF、TNF-α、IL-1β、CA125水平较高,且与患者的临床分期密切相关,可作为临床诊断的重要指标。
Objective To investigate the value of combined detection of serum VEGF, TNF-α, IL-1β and CA125 in the diagnosis of endometriosis. Methods From May 2015 to March 2017, patients with endometriosis undergoing MCH in Hunan Province were selected as the study group and served as the observation group. At the same time, 80 healthy individuals were selected as the control group. The differences of serum VEGF, TNF-α, IL-1β and CA125 levels between the two groups and in the observation group were compared. The levels of CA125 in the patients with endometriosis The correlation between the levels of VEGF, TNF-α, IL-1β and the levels of VEGF, Results The levels of VEGF, TNF-α, IL-1β and CA125 in the observation group were significantly higher than those in the control group (t = -36.588, -45.027, -26.487, -111.105, P <0.001) Serum levels of VEGF, TNF-α, IL-1β and CA125 in patients with syndromes were significantly higher than those in patients with stage Ⅰ-Ⅱ endometriosis (t = -38.815, -7.697, -9.905, -21.326, P <0.001 ). The level of serum CA125 in patients with endometriosis was positively correlated with the levels of VEGF, TNF-α and IL-1β (r = 0.489,0.512,0.538, P = 0.023,0.015,0.002) Specificity and sensitivity of diagnosis of the disease were 45.63 and 35.18, respectively. The specificity and sensitivity of CA125 combined with VEGF, TNF-α and IL-1β in diagnosis of endometriosis were higher, which were 65.32 and 55.86 respectively. Conclusions Serum levels of VEGF, TNF-α, IL-1β and CA125 in patients with endometriosis are high, and are closely related to the clinical stage of the patients, which can be used as an important index in clinical diagnosis.