默克尔细胞(Merkel’s cell)由F.S Merkel在1875年第一次描述,是一种具短指状突起的分布于全身表皮基底细胞之间的细胞,数目少,常位于皮肤附件和触觉感受器丰富的部位,不分枝,通常被认为是一种触觉细胞,并具有神经内分泌功能。Merkel细胞癌与Merkel细胞有相似的形态学、免疫组织化学和超微结构特点,但在组织起源上的直接关联尚未得到证实。Merkel细胞癌是原发于皮肤的一种高度恶性肿 Merkel’s cell, first described by FS Merkel in 1875, is a short-fingered cell population distributed throughout the basal cells of the epidermis of the skin, with a small number of cells, often located in skin-rich appendages and tactile receptors The site, unbranched, is generally considered to be a tactile cell and has neuroendocrine function. Merkel cell carcinoma has similar morphological, immunohistochemical and ultrastructural features to Merkel cells, but no direct evidence of its origins has been established. Merkel cell carcinoma is a highly malignant tumor of the primary skin