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苦碟子为菊科二年生草本植物,学名抱茎苦荬菜 Ixeris sonchifolia Hance,在我省分布较广,资源丰富,过去不列为药用植物。我省建昌地区民间用春秋两季的“碟子”(即没抽茎的苦碟子)作头痛、胃肠痛和某些外伤的止痛用。过去经我们初步观察,该药毒性小,有一定的镇痛、镇静和解平滑肌痉挛作用,临床证明,它对血管神经性头痛和一般的疼痛有一定的止痛作用。近年的临床实践中,由解放军第二○四医院发现,苦碟子制剂对心肌梗塞病人的剧痛有明显的治疗作用,相继治疗几例效果满意,又试用于10例冠心病的治疗,疗效尚好。为证明该药对冠心病的治疗作用和为临床深入研究提供必要的资料,我们对苦碟子(春夏季开花期全草)的药理作用进行如下的研究。
Kudzu is a biennial herb of the Asteraceae family. Its scientific name is Ixeris sonchifolia Hance. It is widely distributed in our province and has abundant resources. It was not classified as a medicinal plant in the past. In the Jianchang area of our province, people use spring and autumn “dishes” (ie, bitter dishes without stems) as an analgesic for headaches, gastrointestinal pain, and some trauma. In the past, our preliminary observation showed that the drug has a low toxicity and certain degree of analgesia, sedation, and smooth muscle spasm. Clinically, it has certain analgesic effects on angioneurotic headache and general pain. In clinical practice in recent years, it was discovered by the No. 204 Hospital of the People’s Liberation Army that the Kudiezi preparation has obvious therapeutic effects on acute pain in patients with myocardial infarction, and several cases of satisfactory results have been treated successively, and they have also been used in the treatment of 10 cases of coronary heart disease. The curative effect is still good. . In order to prove the drug’s therapeutic effect on coronary heart disease and provide necessary information for clinical in-depth study, we studied the pharmacological effects of KD (spring and summer flowering plants) as follows.