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氯霉素具有广谱抗菌活性,而且临床疗效好,是一种常用抗生素。任凭有许多有效的替代药物,但氯霉素仍继续用于治疗许多感染,如中枢神经系统感染、伤寒、立克次氏体病、厌氧菌感染和眼部感染。氯霉素使用受到最大的限制是对病人的血液学毒性。经研究证明,成人氯霉素血清峰浓度需10-20μg/ml才能达到治疗效果,但超过25μg/ml可发生毒性。任凭儿童缺乏治疗量的氯霉素血清浓度与副作用之间的明显关系,但儿科已参照成人相同的治疗药物浓度。因此,在治疗过程中常需监测氯霉素血
Chloramphenicol has a broad spectrum antibacterial activity, and clinical efficacy is good, is a commonly used antibiotics. Despite many potent alternatives, chloramphenicol continues to be used to treat many infections such as CNS infections, typhoid, rickettsiasis, anaerobic infections and ocular infections. The biggest limitation of chloramphenicol use is the hematological toxicity to the patient. Studies have shown that adult chloramphenicol serum peak concentration of 10-20μg / ml to achieve the therapeutic effect, but more than 25μg / ml toxicity may occur. Despite the lack of a therapeutic dose of chloramphenicol serum concentrations and side effects of the obvious relationship, but pediatric has the same adult treatment of drug concentrations. Therefore, it is often necessary to monitor chloramphenicol during the course of treatment