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在钙通道阻滞剂尼卡地平的研究中发现:用5～15mg/kg日尼卡地平,可抑制小鼠的免疫功能,为了进一步了解尼卡地平对免疫器官形态学的影响,我们用10mg/kg日的剂量,对小鼠免疫器官进行了光镜和电镜观察,结果表明:光镜下:胸腺皮质变薄,淋巴细胞减少,髓质淋巴细胞数量有所增加;淋巴结皮髓质交界模糊不清,生发中心减少甚至消失,淋巴小结均小于对照组;脾红髓轻度扩大,白髓萎缩,红髓中淋巴细胞数量减少。电镜下:胸腺皮质细胞间隙变窄,淋巴细胞间可见小泡状结构,细胞表面微绒毛减少,核异染色质增多,部分线粒体肿胀或凝聚、高尔基复合体,粗面内质网较发达;巨噬细胞溶酶体增
In the study of the calcium channel blocker nicardipine, it was found that the use of 5-15 mg/kg zinicapine can inhibit the immune function of mice. To further understand the effect of nicardipine on the morphology of immune organs, we used 10 mg. At the dose of /kg day, light and electron microscopy were performed on the immune organs of mice. The results showed that under the light microscope, the thymus cortex became thin, lymphocytes decreased, the number of medullary lymphocytes increased, and the lymph nodes were blurred It was unclear that the germinal center was reduced or even disappeared. Lymph nodes were smaller than the control group; the splenic red pulp slightly expanded, the white pulp was atrophic, and the number of lymphocytes in the red pulp decreased. Under the electron microscope, the gap between the thymus cortical cells became narrow, small vesicular structure was observed between the lymphocytes, the microvilli on the cell surface decreased, the nuclear heterochromatin increased, part of the mitochondria swollen or condensed, the Golgi complex, and the rough endoplasmic reticulum developed; Lysosome increase