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组蛋白乙酰化和去乙酰化在基因的转录调控中发挥着重要作用,组蛋白乙酰化水平由组蛋白乙酰化酶(HAT)和组蛋白去乙酰化酶(HDAC)的动态平衡调节。HAT和HDAC的异常与肿瘤的发生有着密切的关系。近年来大量研究表明,
Histone acetylation and deacetylation play important roles in the transcriptional regulation of genes, and histone acetylation is regulated by the homeostasis of histone deacetylase (HAC) and histone deacetylase (HDAC). Abnormalities of HAT and HDAC are closely related to tumorigenesis. In recent years, a large number of studies have shown that,