【摘 要】
：
A-nor-Δ3(5),9(10)-estradiene-2,17-dione 1,a potential precursor for synthesis of some new steroidalcontraceptives,was synthesized from 3β-hydroxy-5α-chloro-
【机 构】
：
Shanghai Institute of Organic Chemistry,Chinese Academy of Science's,Shanghai 200032,ChinaDepartment
【出 处】
：
Science in China(Series B)
论文部分内容阅读
A-nor-Δ3(5),9(10)-estradiene-2,17-dione 1,a potential precursor for synthesis of some new steroidalcontraceptives,was synthesized from 3β-hydroxy-5α-chloro-6β,19-epoxy-androstane-17-one 6 as the sterting mater al,which is the key intermediate of steroidal contraceptive of norethindrone,in an overall yield of 25% in 5 steps through the sequence of 5 reactions:(i) oxidative dccyclization,(ii) decarhoxylative cyclization,(iii) reductive decy clization,(iv) dehydroxy methylation,(v) deacetoxylation
A-nor-Δ3 (5), 9 (10) -estradiene-2,17-dione 1, a potential precursor for synthesis of some new steroidal contractivity, was synthesized from 3β-hydroxy-5α-chloro-6β, 19- androstane-17-one 6 as the sterting mater al, which is the key intermediate of steroidal contraceptive of norethindrone, in an overall yield of 25% in 5 steps through the sequence of 5 reactions: (i) oxidative dccyclization, (ii) decarhoxylative cyclization, (iii) reductive decy clization, (iv) dehydroxy methylation, (v) deacetoxylation
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