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目的：研究高压氧暴露对红细胞、淋巴细胞免疫功能的影响及可能机制。方法：小鼠暴露于0．25MPa（2．5ATA）99．2％O2的高压氧下2小时，测定红细胞、淋巴细胞的免疫粘附功能及血浆丙二醛（MDA）含量，血浆β-内啡肽（β-EP）浓度。结果：HBO暴露下红细胞、淋巴细胞免疫粘附功能均下降，同时血浆MDA，β－EP含量升高。结论：HBO暴露可抑制机体免疫功能，这种抑制作用可能与脂质过氧化损伤及神经内分泌调节有关。
Objective: To study the effect of hyperbaric oxygen exposure on immune function of erythrocyte and lymphocyte and its possible mechanism. Methods: Mice were exposed to hyperbaric oxygen of 0.25MPa (2.5ATA) 99.2% O2 for 2 hours. The immune adherence function of erythrocytes and lymphocytes and the content of plasma malondialdehyde (MDA) Enkephalin (β-EP) concentration. Results: The immune function of erythrocyte and lymphocyte decreased after exposure to HBO, meanwhile, the contents of MDA and β-EP in plasma increased. Conclusion: HBO exposure can inhibit the immune function of the body, this inhibition may be related to lipid peroxidation damage and neuroendocrine regulation.