目的 :研究病毒性肝炎患者血清 AAT,PAB水平变化的临床意义。方法 :采用 COBASEMIRA生化分析仪检测 94例病毒性肝炎患者血清标本。结果 :13例 A H组、 45例 CH组、2 8例 L C组、 8例 FH组 A AT,PAB水平均显著低于正常对照组 ( P <0 .0 1) ,FH组与 AH组、 CH组、 L C组比较 A AT,PAB水平下降有显著性差异 ( P<0 .0 5 )。且 AAT与 PAB水平呈正相关 ( r=0 .2 85 ,P<0 .0 1)。结论 :AAT及 PAB血清水平下降与病毒性肝炎患者肝脏病变严重程度有关 ,PAB可作为反映肝脏功能的灵敏指标。 Objective: To study the clinical significance of serum AAT and PAB levels in patients with viral hepatitis. Methods: Serum samples of 94 patients with viral hepatitis were detected by COBASEMIRA biochemical analyzer. Results: The AT and PAB levels in 13 AH patients, 45 CH patients, 28 LC patients and 8 FH patients were significantly lower than those in control group (P <0.01), FH group and AH group, CH There was significant difference between A group and LC group (P <0. 05). And AAT and PAB levels were positively correlated (r = 0.285, P <0.01). Conclusion: The decrease of serum AAT and PAB levels is related to the severity of liver lesions in patients with viral hepatitis, and PAB may be used as a sensitive indicator of liver function.