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目的:探讨原发性胆囊癌外科疗效及预后影响因素。方法:对2001年2月—2008年1月收治的原发性胆囊癌患者的临床资料进行回顾性分析。结果:原发性胆囊癌患者治疗后3,5年生存率较低;单因素分析结果提示:无梗阻性黄疽症状,N分期,AJCC分期,T分期越高,肿瘤分化程度较低,维吾尔族患者其预后差;多因素分析结果提示:黄疸(OR=2.736,95%CI=1.721~3.291),肿瘤分化程度(OR=1.726,95%CI=1.328~2.938),AJCC分期(OR=1.372,95%CI=0.827~2.192,处理方式(OR=1.382,95%CI=0.763~2.328),民族(OR=1.382,95%CI=0.872~4.382)是影响原发性胆囊癌患者其预后的独立危险因素。结论:原发性胆囊癌外科诊疗其预后较差,其与黄疸、肿瘤分化程度、AJCC分期、处理方式和民族有关。
Objective: To investigate the surgical efficacy and prognostic factors of primary gallbladder cancer. Methods: The clinical data of patients with primary gallbladder carcinoma admitted from February 2001 to January 2008 were analyzed retrospectively. Results: The survival rates of patients with primary gallbladder cancer at 3 and 5 years after treatment were low. The results of univariate analysis suggested that the symptoms of non-obstructive jaundice, N stage, AJCC stage and T stage were lower, (OR = 1.736, 95% CI = 1.328-2.938), AJCC stage (OR = 1.372, 95% CI = 1.721-3.391), the degree of tumor differentiation (OR = 1.382, 95% CI = 0.763 ~ 2.328), nationality (OR = 1.382, 95% CI = 0.872 ~ 4.382) were the prognostic factors of patients with primary gallbladder cancer Independent risk factors.Conclusion: Surgical diagnosis and treatment of primary gallbladder cancer has a poor prognosis, which is related to jaundice, tumor differentiation, AJCC staging, treatment methods and ethnic groups.