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[目的]探讨四跨膜蛋白CD151在膀胱尿路上皮细胞癌中的表达及意义。[方法]采用免疫组化法检测112例膀胱尿路上皮细胞癌和20例正常组织中CD151蛋白的表达。[结果]正常组织中CD151蛋白表达水平明显低于肿瘤组织(P<0.001)。低级别和高级别膀胱癌中CD151蛋白表达的阳性率分别为38.2%、66.7%(P=0.005)。非肌层浸润性膀胱癌和肌层浸润性膀胱癌中CD151蛋白表达的阳性率47.9%、76.9%(P=0.003)。73例非肌层浸润性膀胱癌73例中,复发40例,复发组与未复发组CD151蛋白表达的阳性率分别为65.0%和27.3%(P=0.001)。[结论]CD151蛋白在膀胱癌组织中表达明显高于正常组织,CD151蛋白检测有助于判断肿瘤恶性分化程度及评估术后复发。
[Objective] To investigate the expression of four-transmembrane protein CD151 in bladder urothelial carcinoma and its significance. [Method] The expression of CD151 in 112 cases of bladder urothelial carcinoma and 20 cases of normal tissues was detected by immunohistochemistry. [Results] The expression of CD151 protein in normal tissues was significantly lower than that in tumor tissues (P <0.001). The positive rates of CD151 protein in low-grade and high-grade bladder cancer were 38.2% and 66.7% (P = 0.005) respectively. The positive rate of CD151 protein in non-muscle invasive bladder cancer and myometrial invasive bladder cancer was 47.9% and 76.9%, respectively (P = 0.003). In 73 cases of 73 cases with non-muscle invasive bladder cancer, 40 cases relapsed, the positive rates of CD151 protein expression in relapsed and non-relapsed cases were 65.0% and 27.3%, respectively (P = 0.001). [Conclusion] The expression of CD151 protein in bladder cancer tissues is significantly higher than that in normal tissues. The detection of CD151 protein is helpful to determine the degree of malignant differentiation and evaluate the recurrence after operation.