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目的:探讨女性宫颈病变与感染高危型人乳头瘤病毒(HR-HPV)的相关性。方法:选取自愿参与宫颈病变筛查的已婚或有性生活史妇女2258例为研究对象并采用杂交导流技术对宫颈分泌物进行HPV感染检测,同时对所有参与研究的患者进行病理组织学检查。结果:2 258例中共检测感染HR-HPV患者446例,HR-HPV阳性率为19.75%;各种类型的HR-HPV感染率从高至低依次为HPV16、31、52、58、18、53、59,其中重叠感染率为8.06%(182/2 258);随着妇女年龄的增长(除了35～39岁),HR-HPV感染率也随之增大。经病理组织学检查2 258例中共有78例为宫颈病变,病变率为3.45%;其中子宫颈癌11例,CINⅢ20例,CINⅡ24例,CINⅠ23例。与正常妇女相比,宫颈病变患者HR-HPV阳性率显著增高(P<0.05),与宫颈病变程度呈正相关。结论:HR-HPV的感染与妇女的年龄有密切关系,年龄越高的患者感染风险越大,同时子宫颈病变程度与HR-HPV的感染呈正相关,定期对妇女进行宫颈疾病筛查是预防宫颈病变的有效措施。
Objective: To investigate the correlation between female cervical lesions and high-risk human papillomavirus (HR-HPV) infection. Methods: Totally 2258 married or sex life-history women who voluntarily participated in the screening of cervical lesions were enrolled in this study. The cervical secretions were tested for HPV infection by hybridization diversion technique, and all the patients involved in the study were pathologically examined . Results: A total of 2 258 cases of HR-HPV infection were detected in 446 cases, the HR-HPV positive rate was 19.75%. The highest HR-HPV infection rates of all types were HPV16, 31, 52, 58, 18, 53 , 59, of which the overlap infection rate was 8.06% (182/2 258). As the women’s age increased (except 35-39 years old), the HR-HPV infection rate also increased. Pathological examination of 2 258 cases of a total of 78 cases of cervical lesions, the rate was 3.45%; of which 11 cases of cervical cancer, CIN Ⅲ 20 cases, CIN Ⅱ 24 cases, CIN Ⅰ 23 cases. Compared with normal women, the positive rate of HR-HPV in cervical lesions was significantly higher (P <0.05), which was positively correlated with the degree of cervical lesions. Conclusion: The HR-HPV infection is closely related to the age of women. The higher the age, the higher the risk of infection. At the same time, the degree of cervical lesions is positively correlated with HR-HPV infection. Regular screening of women with cervical diseases is the prevention of cervical Effective measures of the disease.