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目的 评估局限性胸膜肺切除术治疗伴癌性胸水非小细胞肺癌的远期效果和应用价值。 方法 对1994年 1月至 1998年 12月间采用该术式治疗的 16例伴癌性胸水肺癌患者进行定期随访 ,了解患者生活质量、复发情况和生存时间。计算术后中位数复发和中位数生存时间。 结果 本组无手术死亡 ,无严重手术并发症。术后胸闷、呼吸困难、胸腹壁疼痛症状明显缓解 ,恶病质迅速消失 ,未见胸水复发 ,但后期均发生远处脏器转移。术后肿瘤复发距手术时间 3~ 36个月 ,中位数复发时间 12个月。随访至 2 0 0 0年 8月 ,所有病例死亡 ,存活期 7~ 39个月。存活 1年以上 15例 ,1年生存率 94% ;存活 18个月以上 13例 ,生存率 81% ;存活 2年以上 7例 ,生存率 44 % ;存活 3年以上 2例 ,生存率 13% ;中位数生存期 2 1.5个月。 结论 此术式控制胸水、缓解症状效果肯定。术后晚期均发生远处脏器转移 ,但其中位数生存期明显长于仅做姑息性肺内癌灶切除或内科治疗患者 ,且长于全胸膜肺切除术。本术式有推广应用价值
Objective To evaluate the long-term efficacy and application value of limited pleural pneumonectomy in the treatment of non-small cell lung cancer with pleural effusion. Methods Sixteen patients with CWC who underwent this operation between January 1994 and December 1998 were followed up regularly to find out the quality of life, relapse and survival time. Calculate the median postoperative recurrence and median survival time. Results of this group no operative death, no serious complications. Postoperative chest tightness, difficulty breathing, chest and abdomen pain symptoms were relieved, cachexia disappeared rapidly, no recurrence of pleural effusion, but late occurred in distant organs metastasis. Tumor recurrence after surgery from 3 to 36 months, the median recurrence time of 12 months. All cases were followed up until August 2000, with a median survival of 7 to 39 months. Survival of more than 1 year in 15 cases, 1 year survival rate of 94%; survival of more than 18 months in 13 cases, the survival rate of 81%; survival of more than 2 years in 7 cases, survival rate of 44%; survival of 3 years in 2 cases, 13% ; Median survival 2 1.5 months. Conclusion This technique controls the pleural effusion and relieves the symptoms. Long-term postoperative metastases of distant organs occurred, but the median survival was significantly longer than only palliative intra-lung cancer resection or medical treatment of patients, and longer than the total pleural pneumonectomy. This technique has the promotion and application value