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目的：探讨糖尿病患者骨质疏松的发生率及敏感检测指标。方法：对４６例糖尿病患者和对照组４６名正常人，用放射免疫法测定血清骨钙素，用单光子吸收法测定骨密度，并对骨钙素与骨密度进行相关分析。同时检测血钙、磷、碱性磷酸酶等。结果：糖尿病患者的骨钙素［（３．３±１．４）μｇ／Ｌ］与骨密度［（０．６７±０．１１）ｇ／ｃｍ２］均明显低于对照组［分别为（４．６±１．２）μｇ／Ｌ、（０．７８±０．１２）ｇ／ｃｍ２］，（Ｐ＜０．００１）。骨钙素水平与骨密度呈正相关（γ＝０．５９０２，Ｐ＜０．００１），与病程及血糖呈负相关（γ＝－０．６７６０，－０．４５ １２，Ｐ＜０．０１～０．００１）。血钙、磷、碱性磷酸酶属正常范围。糖尿病患者骨量减少１４例（３０％），骨质疏松１１例（２４％），而对照组骨量减少４例（９％），未发现骨质疏松者。结论：糖尿病患者骨质疏松发生率较高。骨钙素可以作为检测糖尿病性骨质疏松的敏感指标。
Objective: To investigate the incidence of osteoporosis in diabetic patients and the sensitive detection indexes. Methods: Forty - six patients with diabetes and 46 controls were enrolled in this study. Serum osteocalcin was measured by radioimmunoassay. Bone mineral density (BMD) was measured by single photon absorption spectrophotometry. Correlation analysis between osteocalcin and bone mineral density was performed. Simultaneous detection of blood calcium, phosphorus, alkaline phosphatase. Results: The osteocalcin (3.3 ± 1.4) μg / L and BMD in diabetic patients [(0.67 ± 0.11) g / cm2] were significantly lower than those in the control group [(4 .6 ± 1.2) μg / L, (0.78 ± 0.12) g / cm2] (P <0.001). Osteocalcin was positively correlated with bone mineral density (γ = 0.5902, P <0.001), and had a negative correlation with disease duration and blood glucose (γ = -0.6760, -0.45 12, P <0.01 ~ 0.001). Calcium, phosphorus, alkaline phosphatase is a normal range. In the diabetic group, osteopenia was reduced in 14 (30%) and osteoporosis in 11 (24%), whereas in the control group osteopenia was found in 4 (9%) and no osteoporosis was found. Conclusion: The incidence of osteoporosis in diabetic patients is high. Osteocalcin can be used as a sensitive indicator of diabetic osteoporosis.