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目的探讨血浆内皮素(ET)与先心病肺动脉高压的关系以及手术纠治缺损后ET的变化。方法对41例先心患者,其中肺动脉高压20例(A组)、正常肺动脉压21例(B组)进行手术前后ET值及有关血流动力学指标检测并进行对照分析。结果A组病人ET浓度明显高于B组;A组病人的肺动脉压、平均肺动脉压、肺毛细血管楔压及肺血管阻力均与ET有线性正相关;手术后A组病人肺动脉压均有明显下降,并且血浆ET浓度显著下降;B组病人ET无明显变化。结论ET浓度升高在先心病肺动脉高压的形成病理过程中起重要作用。
Objective To investigate the relationship between plasma endothelin (ET) and pulmonary hypertension in patients with congenital heart disease (CAD) and the changes of ET after surgery. Methods Twenty-one patients with congenital heart disease, including 20 cases of pulmonary hypertension (group A) and 21 cases of normal pulmonary arterial pressure (group B), were examined by ET and related hemodynamics before and after surgery. Results The ET level in group A was significantly higher than that in group B. The pulmonary arterial pressure, mean pulmonary arterial pressure, pulmonary capillary wedge pressure and pulmonary vascular resistance in group A were positively correlated with ET. The pulmonary arterial pressure in group A was significantly higher after operation Decreased, and plasma ET concentration decreased significantly; group B patients ET no significant change. Conclusions Elevated ET concentration plays an important role in the pathogenesis of pulmonary hypertension in CHD.