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氯头孢菌素(Cefaclor)为治疗小儿急性中耳炎的有效药物。口服后,从正常的胃肠道吸收良好。已知短肠综合症病人降低许多营养物质的吸收。可是,人们尚不太清楚患有此症病人对于药物的吸收情况。因此,现报道一例患有短肠综合症病人用口服氯头孢菌素混悬液治疗中耳炎的情况。该病人的氯头孢菌素血清浓度显著地低于以前报道的接受同剂量的儿科病人。按每公斤给药15mg,1小时后,在进食病人中氯头孢菌素为平均血药浓度(7.5μg/ml)的18%,禁食病人中为平均血药浓度(11.5μg/ml)的12%。
Cefaclor (Cefaclor) is an effective drug for the treatment of acute otitis media in children. After oral administration, good absorption from the normal gastrointestinal tract. Patients with short bowel syndrome are known to reduce the absorption of many nutrients. However, it is not yet clear how much the patient suffers from the drug’s absorption. Accordingly, a case of otitis media with oral cefazolin suspension in patients with short bowel syndrome is now reported. The patient’s serum levels of chlorocephalospores were significantly lower than previously reported pediatric patients at the same dose. At 15 mg / kg, after 1 hour, cefazolin was 18% of the mean plasma concentration (7.5 μg / ml) in the fed patients and was equal to the mean plasma concentration (11.5 μg / ml) in the fasted patients 12%.