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目的探讨尼莫地平对高血压脑出血的血肿吸收及神经功恢复的影响。方法选择发病24h内入院的高血压脑出血患者随机分为治疗组和对照组。治疗组应用尼莫地平注射液10mg/d,连续用14d后,改为尼莫地平40mg每日3次口服,共用28d。对照组除不用尼莫地平外,其他治疗同对照组。分别比较两组患者治疗不同时期血肿、水肿体积及CSS评分和BI指数,并比较两组的治疗效果。结果2周时,治疗组血肿+水肿体积较对照组小,CSS评分低于对照组,差异具有统计学意义(P<0.05);4周时,治疗组血肿体积和血肿+水肿体积均较对照组明显缩小,CSS评分明显低于对照组,差异具有统计学意义(P<0.01),BI指数高于对照组,差异具有统计学意义(P<0.05);3月时,治疗组CSS评分明显低于对照组,BI指数明显高于对照组,差异具有显著意义(P<0.01)。结论尼莫地平早期应用于高血压脑出血的治疗有利于血肿的吸收,脑水肿的减轻,可改善脑出血患者的预后。
Objective To investigate the effect of nimodipine on hematoma absorption and neurological recovery in patients with hypertensive intracerebral hemorrhage. Methods Patients with hypertensive intracerebral hemorrhage admitted within 24 hours after onset were randomly divided into treatment group and control group. Treatment group nimodipine injection 10mg / d, continuous use 14d, changed to nimodipine 40mg orally three times daily for 28d. In addition to the control group without nimodipine, the other treatment with the control group. The hematoma, edema volume, CSS score and BI index of the two groups were compared, and the treatment effect was compared between the two groups. Results At 2 weeks, the volume of hematoma and edema in the treatment group was smaller than that in the control group, and the CSS score was lower than that in the control group (P <0.05). At 4 weeks, the hematoma volume and hematoma + edema volume (P <0.01). The BI index was higher than that of the control group (P <0.05). At March, the CSS score of the treatment group was significantly higher than that of the control group BI index was significantly lower than that of the control group, the difference was significant (P <0.01). Conclusion The early application of nimodipine in the treatment of hypertensive intracerebral hemorrhage is beneficial to the absorption of hematoma and the reduction of cerebral edema, which can improve the prognosis of patients with intracerebral hemorrhage.