目的 针对心手综合征发病特点,通过文献学习,提高对该病的认识.方法 依据临床诊断标准,对伴有心脏及上肢异常病例进行归纳分析.结果 4例病患均符合临床诊断标准.其中2例为母女关系,具有家族性发病特点;2例为散发性发病.结论 提高对心手综合征认识,对有效降低或预防此类出生缺陷有一定的参考价值.“,”Objective To improve the recognition of Holt-Oram syndrome, we probed into the clinical characters of this syndrome and reviewed the related literatures.Methods According to clinical diagnostic standard.we analyzed cases with congenital heart disease and upper extremity deformities.Results 4 cases met the criteria for clinically significant, 2 cases who were the mother-daughter relationship had familiar sex, 2 cases were sporadic.Conclusions It was significant to reduce or prevent such birth defect through the recognition of Holt-Oram syndrome.