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应用高效液相色谱法分析尿中2-硫代噻唑烷-4-羧酸(TTCA)。54名非接触者的结果示个体差异较大,频数分布呈明显偏态,几何平均水平约0.06mg/g肌酐。9名非接触者的动态观察表明,同一个体有时检出、有时检测不出,每天排泄总量平均0.046mg,未见明显规律。接触二硫化碳工人班前尿TTCA排泄特征与非接触者一样,几何平均水平0.08mg/g肌酐;不同接触水平者次日班前尿、工作周连续每日班前尿TTCA均无明显差异,提示尿TTCA无蓄积性,接触后16h能完全排出体外;接触者班未尿TTCA明显上升,呈现群体接触效应关系。取生物监测临界值0.3mg/g肌酐,尿TTCA反映二硫化碳接触特异度、敏感度和阳性预测值分别是87％、84％和86％。可用于二硫化碳接触的群体生物监测。
Urinary 2-thiazolidine-4-carboxylic acid (TTCA) was analyzed by high performance liquid chromatography. The results of 54 non-contact individuals showed large individual differences, a significant skewed frequency distribution with a geometric mean of about 0.06 mg / g creatinine. Dynamic observation of 9 non-contact subjects showed that the same individual was sometimes detected, sometimes undetectable, the average amount of daily excretion of 0.046mg, no obvious rules. The urinary TTCA excretion characteristics of workers exposed to carbon disulfide classes were the same as that of non-contact persons. The geometric mean level was 0.08mg / g creatinine. Urine TTCA was not significantly different from the same day after class on the second day after different exposure levels, TTCA without accumulation, after 16h contact can be completely excreted; contact with urine TTCA significantly increased, showing a population contact effect. Take creature monitoring threshold 0.3mg / g creatinine, urinary TTCA reflect carbon disulfide contact specificity, sensitivity and positive predictive value were 87%, 84% and 86%. Can be used for biological monitoring of carbon disulfide exposure.