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目的:通过对母婴ABO血型不合及Rh血型不合的新生儿溶血病血清学检测结果进行回顾性分析,探究血型血清学检测对新生儿溶血病产前诊断的价值。方法:选择我院收治268例出现不同程度黄染或怀疑为溶血病的新生儿,回顾性分析孕妇产前抽取血液进行血型鉴定、抗红细胞不规则抗体筛查、Ig G抗A或抗B效价检测结果。结果:抗红细胞不规则抗体筛查阳性、Ig G抗A或抗B效价≥64与产后发生HDN呈正相关性,并且随着抗体效价升高呈上升趋势,抗体效价≥1024时全部发生HDN;采血检测结果中阳性标本223例,研究新生儿中溶血症阳性率为83.3%,0-3天、4-7天、7-10天、10-15天新生儿结果阳性率分别为26.5%、48.4%、20.6%、4.5%。产前血型血清学检测结果准确率为93.3%(208/223)。结论:针对胎儿母亲进行血型血清学检测,可以准确预估胎儿溶血病发生率,因此对母婴ABO血型不合及Rh血型不合进行早期血型血清学检测,对早发现、早预防、早治疗新生儿溶血具有重要意义。
OBJECTIVE: To investigate the value of serological detection in the prenatal diagnosis of neonatal hemolytic disease by retrospectively analyzing serological results of neonatal hemolytic disease of incompatible ABO and Rh blood group. Methods: A total of 268 newborns with different degree of yellow dye or suspected hemolytic disease were admitted to our hospital. Blood samples were collected from prenatal pregnant women for retrospective analysis of blood type, anti-RBC antibody screening, Ig G anti-A or anti-B effect Price test results. Results: The screening of anti-RBC irregular antibodies was positive. Ig G anti-A or anti-B titers≥64 was positively correlated with postnatal HDN, and the antibody titers tended to increase with antibody titers increasing HDN; blood samples were positive in 223 cases, the positive rate of hemolytic disease in newborns was 83.3%, the positive rates of 0-3 days, 4-7 days, 7-10 days and 10-15 days neonates were 26.5 %, 48.4%, 20.6%, 4.5%. The accuracy of prenatal blood group serological test was 93.3% (208/223). Conclusion: According to the blood type serology test of fetus mother, it can accurately predict the incidence of fetus hemolytic disease. Therefore, the early blood group serological tests on ABO incompatibility and Rh blood group incompatibility in maternal and neonates, and early detection, early prevention, early treatment of newborns Hemolysis is of great importance.