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对１０例健康志愿者静脉恒速滴注氧氟沙星２００ｍｇ（３０ｍｉｎ）注射液后的药物动力学进行了研究。用高效液相色谱法及微生物法分别对血清及尿中氧氟沙星进行测定。其体内过程符合二室开放模型，主要药动学参数分别是：滴注完时浓度Ｃ０为５．１５±１．６３ｍｇ／Ｌ，清除相半衰期为４．８６±０．１８ｈ，ＡＵＣ为１５．８９±２．８６ｈ·ｍｇ／Ｌ，中央室表现分布容积Ｖｃ为３５．０６±１１．０４Ｌ，０～２４小时内尿中排泄原药的７８．９％±１０．９％。
The pharmacokinetics of ofloxacin 200 mg (30 min) intravenous infusion in 10 healthy volunteers were studied. Determination of ofloxacin in serum and urine by high performance liquid chromatography and microbiological method respectively. The in vivo process accords with the two-compartment open model. The main pharmacokinetic parameters are as follows: the concentration C0 at the end of instillation is 5.15 ± 1.63 mg / L, the elimination half-life is 4.86 ± 0.18 h, and the AUC is 15. 89 ± 2.86h · mg / L, the central volume Vc was 35.06 ± 11.04L, and the excretion of urine was 78.9% ± 10.9% within 0 ~ 24 hours.