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目的探讨老年癌症骨转移患者内照射治疗的剂量效应。方法对用１５３钐－乙二胺四甲撑膦酸（１５３Ｓｍ－ＥＤＴＭＰ）治疗而缓解癌性骨痛的老年患者４０例作骨辐射吸收剂量分析和疗效观察，并以老年前期组４０例癌性骨痛治疗者为对照。结果老年组及老年前期两组在尿排泄率、骨摄取率及骨累积活度的差异无显著性；其疗效分别为４５％及６０％，老年组稍低于老年前期组，但差异无显著性（均为Ｐ＞０．０５）；红骨髓辐射吸收剂量相似，分别为２１９．９±６８．２及２０６．３±６４．７ｃＧｙ，均在安全剂量范围（２８５ｃＧｙ）内。结论增龄不影响老年人１５３Ｓｍ－ＥＤＴＭＰ治疗缓解癌性骨痛的剂量效应。
Objective To investigate the dose effect of internal radiation therapy in elderly patients with bone metastases. Methods 40 cases of elderly patients with cancer-related bone pain treated with 153钐-ethylenediamine tetramethylphosphonic acid (153Sm-EDTMP) were used for bone resorption dose analysis and efficacy observation, and 40 cases of precancerous group were cancerous. Treatment of bone pain was controlled. Results There was no significant difference in urinary excretion rate, bone uptake rate and bone accumulation activity between the elderly group and the old age group. The curative effect was 45% and 60% respectively. The old group was slightly lower than the pre-senile group, but the difference was not significant. Both sexes (all P>0.05); red bone marrow radiation absorption doses were similar, 219.9±68.2 and 206.3±64.7 cGy, respectively, both in the safe dose range (285cGy). Conclusions Ageing does not affect the dose-effect of 153Sm-EDTMP in elderly patients with cancer pain relief.