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近年临床资料分析,胰岛素抵抗与多囊卵巢综合征(PCOS)患者子宫内膜增生存在很高的一致性,且PCOS患者患子宫内膜癌的几率高。近年研究发现,胰岛素除有促代谢的作用外,其促细胞生长、增生的作用越来越受到重视,且与多种肿瘤的发生机制有关。PCOS胰岛素抵抗与子宫内膜病变的机制可从几方面分析:胰岛素抵抗影响体内性激素水平;胰岛素本身促进细胞增殖分化;胰岛素抵抗影响体内胰岛素样生长因子的水平;胰岛素抵抗与基因表达异常的细胞协同促进细胞增生,加速了细胞恶变。
In recent years, clinical data analysis, insulin resistance and polycystic ovary syndrome (PCOS) patients with endometrial hyperplasia there is a high degree of consistency, and PCOS patients with high risk of endometrial cancer. In recent years, studies have found that insulin in addition to the role of metabolic promotion, the role of cell growth, proliferation more and more attention, and with a variety of tumor pathogenesis. The mechanism of PCOS insulin resistance and endometrial lesions can be analyzed from several aspects: insulin resistance affects the level of sex hormone in the body; insulin itself promotes cell proliferation and differentiation; insulin resistance affects the level of insulin-like growth factor in vivo; insulin resistance and cellular abnormalities of gene expression synergies Promote cell proliferation, accelerated cell malignant.