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目的:评价奥沙利铂联合氟尿嘧啶、亚叶酸钙结合同期放疗的疗效。方法:奥沙利铂(L-OHP)130mg/m~2静脉滴注2小时,第1天;氟尿嘧啶(5-FU)300mg/m~2静脉滴注,第1～5天,亚叶酸钙(CF)200 mg/m~2静脉滴注,第1～5天,21天为1周期,治疗3周期。放疗与化疗同期进行,体外照射全盆腔DT 50～60 GY/25～30次(5～6周)。结果:共治疗30例,近期疗效完全缓解(CR)1例;部分缓解(PR)15例;总有效率53.3%。一年生存率为70%(21/30)。主要毒副反应是消化道反应、神经毒性、放射性直肠炎,骨髓抑制轻微。结论:奥沙利铂为主的联合化疗结合同期放疗是治疗晚期直肠癌的有效方法。
Objective: To evaluate the efficacy of oxaliplatin plus fluorouracil and leucovorin combined with concurrent radiotherapy. Methods: The intravenous drip of oxaliplatin (L-OHP) 130mg / m ~ 2 for 2 hours, the first day, the intravenous infusion of 5-fluorouracil 300mg / m ~ (CF) 200 mg / m ~ 2 intravenous drip, 1 to 5 days, 21 days for the 1 cycle, the treatment of 3 cycles. Radiotherapy and chemotherapy in the same period, in vitro irradiation of the whole pelvis DT 50 ~ 60 GY / 25 ~ 30 times (5 ~ 6 weeks). Results: A total of 30 cases were treated with CR (immediate response) in 1 case and partial remission (PR) in 15 cases with a total effective rate of 53.3%. One-year survival rate was 70% (21/30). The main side effects are gastrointestinal reactions, neurotoxicity, radiation proctitis, minimal myelosuppression. Conclusion: Oxaliplatin-based combination chemotherapy combined with concurrent radiotherapy is an effective method for the treatment of advanced rectal cancer.