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目的探讨在新生儿缺氧缺血性脑病(H IE)治疗中常规应用西米替丁预防消化道出血的临床效果。方法228例H IE患儿随机分为观察组123例,对照组105例。观察组在对照组治疗基础上加用西米替丁7.5mg/kg静脉滴注,2次/d,7d为一疗程。结果观察组发生消化道出血2例(1.63%),对照组9例(8.57%),两组比较χ2=5.9507,P<0.05。结论H IE治疗中常规加用西米替丁能有效预防消化道出血的发生。
Objective To investigate the clinical effect of conventional cimetidine on prevention of gastrointestinal bleeding in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods A total of 228 children with HIE were randomly divided into observation group (123 cases) and control group (105 cases). The observation group was given intravenous infusion of cimetidine 7.5 mg / kg on the basis of the control group, twice a day for 7 days. Results In the observation group, 2 cases (1.63%) had gastrointestinal bleeding and 9 cases (8.57%) in the control group, χ2 = 5.9507, P <0.05. Conclusions Hime treatment with cimetidine can effectively prevent the occurrence of gastrointestinal bleeding.