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目的探讨妊娠期肝内胆汁淤积症(ICP)患者的临床特点、终止妊娠方式的选择及对围生儿预后的影响。方法选择2008年3月—2011年3月分娩的100例妊娠期肝内胆汁淤积症患者作为观察组,同期选取住院分娩的正常孕妇120例作为对照组,比较两组孕妇及新生儿情况以及观察组中分娩方式不同对新生儿的影响。结果两组的早产、胎儿宫内窘迫、死亡及羊水污染明显高于对照组(P<0.05);观察组孕妇血清总胆汁酸值不同对新生儿的影响亦不同。结论妊娠期肝内胆汁淤积症对母婴,特别是新生儿的危害极大,导致早产、胎儿宫内窘迫、胎死宫内、产后出血等并发症,增加了围生儿发病率和死亡率。因此应加强孕妇的健康教育,高度重视产前检查和中期妊娠胆汁酸的监测,做到早发现、早治疗,对减少母婴并发症有重要作用。
Objective To investigate the clinical characteristics of patients with intrahepatic cholestasis of pregnancy (ICP), the choice of termination of pregnancy and prognosis of perinatal children. Methods From March 2008 to March 2011, 100 cases of intrahepatic cholestasis of pregnancy were selected as the observation group. 120 pregnant women were selected as the control group during the same period. The pregnant women and newborns in the two groups were compared and observed Effect of different modes of delivery on newborns in the group. Results The preterm birth, fetal distress, death and amniotic fluid contamination in the two groups were significantly higher than those in the control group (P <0.05). The effects of different total bile acid values on the newborns in the observation group were also different. Conclusion Intrahepatic cholestasis of pregnancy is extremely harmful to maternal and infant, especially neonates, resulting in complications such as premature labor, fetal distress, fetal death and postpartum hemorrhage, and increased perinatal morbidity and mortality . Therefore, we should strengthen the health education of pregnant women, attach great importance to the monitoring of bile acids in prenatal care and mid-term pregnancy so that early detection and early treatment play an important role in reducing maternal and child complications.