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本文报道应用30mg的二亚硝基哌嗪作为始动因子,用对EB病毒有漱活作用的黄芜花作为促进因子,进行诱发大鼠鼻咽癌的实验。将89只二月龄大鼠分为四组:A、二亚硝基哌嗪+黄芫花组;B、黄花芫组;C、二亚硝基哌嗪组;D、空白对照组。分别给药,停药后连续观察257～330天,处死、取完整鼻咽连续切片检查。结果表明:在二亚基哌嗪+黄芫花组存活的22只大鼠中,有三例鼻咽粘膜发生癌变(一例为原位癌,二例为早期浸润癌),发癌率达13.6％。其余三组均未见癌发生。因此,黄芫花在此诱癌过程中很可能起促癌因子的作用。临床上对黄芫花似宜慎用。
In this paper, 30 mg of dinitrosopiperazine was used as an initiating factor to induce rat nasopharyngeal carcinoma by using scutellaria baicalensis that has a deterrent effect on EB virus as a promoting factor. 89 two-month-old rats were divided into four groups: A, dinitrosopiperazine + astragalus group; B, Huanghuayu group; C, dinitrosopiperazine group; D, blank control group. Separately administered, observed for 257 to 330 days after discontinuation of the drug, and were sacrificed and consecutive excision of the intact nasopharyngeal was performed. The results showed that of the 22 rats that survived in the diazipirazine + jatropha group, there were three cases of nasopharyngeal mucosal carcinogenesis (one case was carcinoma in situ and two cases were early invasive carcinoma). The cancer rate was 13.6%. No cancer occurred in the other three groups. Therefore, jacaranda is likely to act as a pro-cancer factor in this process of carcinogenesis. Clinically appropriate for the use of yellow flowers.