目的 :研究垂体腺瘤患者血浆和肿瘤组织中的神经肽Y(NPY)浓度与垂体腺瘤的关系。方法 :放射免疫分析方法测定 3 3例垂体腺瘤组织和 2 0例病人血浆的NPY浓度。结果 :不同类型垂体腺瘤组织中NPY含量有显著差别 ,侵袭性垂体腺瘤NPY含量高于非侵袭性垂体腺瘤。肿瘤组织与血浆NPY水平呈正相关。结论 :不同类型垂体腺瘤组织和血浆中NPY含量有显著差别 ,NPY水平可作为垂体腺瘤侵袭性的参考指标之一 Objective: To study the relationship between the concentration of neuropeptide Y (NPY) in pituitary adenoma and pituitary adenoma in patients with pituitary adenoma. METHODS: Radioimmunoassay was used to determine the plasma NPY concentrations in 33 pituitary adenomas and 20 patients. RESULTS: There was a significant difference in NPY content in different types of pituitary adenomas. The content of NPY in invasive pituitary adenomas was higher than that in non-invasive pituitary adenomas. There was a positive correlation between tumor tissue and plasma NPY levels. Conclusion : There is a significant difference in NPY content between different types of pituitary adenomas and plasma. NPY level can be used as one of the reference indexes of pituitary adenoma invasiveness.