汉防己甲素是从防己科植物中提取的一种双苄基异喹啉类生物碱,该药对实验性矽肺具有明显的预防和治疗效果。临床试用证明:使用足够的剂量,在短时间内,于部分病人的X线胸片上,可以见到团块状阴影或结节影有缩小、消散的趋向。本实验的目的,是进一步观察不同剂量汉防己甲素使矽肺病变逆转的作用,为在临床应用中所见到的变化提供实验依据。方法选用健康大鼠,气管内一次注入酸处理石英粉尘50毫克。3个月后处死部分动物,经组织病理学检查,证实肺内病变确已达到基本胶元化阶段,即开始给未处死病鼠用药(汉防己甲素由天津医药工业研究 Tetrandrine is a bis-benzylisoquinoline alkaloid extracted from plants of the family Tetranychus, which has significant preventive and therapeutic effects on experimental silicosis. Clinical trials prove that: With enough doses, in a short period of time, in some patients on the X-ray, you can see the mass of shadow or nodules shadow to reduce, dissipate the trend. The purpose of this experiment is to further observe the effect of different doses of tetrandrine on the reversal of silicosis lesions and to provide experimental evidence for the changes seen in clinical applications. Methods Healthy rats were used to inject acid 50 mg of quartz dust into the trachea. Some animals were sacrificed 3 months later. Histopathological examinations confirmed that the lesions in the lungs had reached the stage of basic collagenization. They began to be administered to untreated rats. (Tetrandrine was researched by Tianjin Pharmaceutical Industry.)