以头痛为首发症状的氨苄青霉素慢性过敏1例报告

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1 病历摘要 女患,39岁,工人。因右上腹持续性疼痛3小时,于1994年7月2日入院。既往无药物过敏史。查体T37.2,P92,Bp17/11。右上腹有压痛,并向右肩放射,莫非氏征阳性。实验室检查:血常规正常。B超符合胆囊炎改变。诊断胆囊炎。用氨苄青霉素治疗。给药前青霉素钠皮试阴性,用氨苄青霉素6g,加生理盐水500ml静点。用药第2天,患者自述头痛、恶心、全身不适,未介意继续用药,第3天静点完,患者头痛难忍,气促,疑有脑部病变,到县医院做头部CT扫描,结果正常,给予对症治疗,头痛缓解。第4天继续静点氨苄青霉素,输液约150ml时,患者再次出现头 1 medical record Female patient, 39 years old, worker. Due to persistent pain in the right upper quadrant for 3 hours, he was admitted on July 2, 1994. Past history of drug allergy. Physical examination T37.2, P92, Bp17 / 11. The right upper quadrant has tenderness and radiates to the right shoulder, is it right? Laboratory tests: normal blood. B super in line with cholecystitis changes. Diagnosis of cholecystitis. With ampicillin treatment. Penicillin sodium skin test before administration negative, with ampicillin 6g, plus saline 500ml static point. On the second day after treatment, the patient reported headache, nausea and general malaise, and did not mind to continue the medication. After the third day of intravenous injection, the patient suffered headache, shortness of breath, suspected brain disease and CT scan to the county hospital. The result Normal, given symptomatic treatment, headache relief. On the fourth day continue ampicillin, infusion of about 150ml, the patient appeared again head
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