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患儿女,9岁。因外阴出现黑色丘疹1个月余,渐加重1周。患儿外阴散在或聚集分布黑色扁平丘疹,部分融合成斑块。外阴皮损组织病理检查显示,角化过度,棘层增厚和表皮突增宽,细胞结构紊乱,全层可见非典型细胞,但基膜完整。皮损免疫组化结果示人乳头瘤病毒(HPV)阳性。PCR-反向点杂交法检测结果 HPV-16(高危型)阳性。依据临床及实验室检查确诊为由HPV-16感染引起的鲍恩样丘疹病。给予5-氨基酮戊酸(ALA)光动力疗法(PDT)治疗3次,外阴皮损全部消退。之后外用咪喹莫特软膏维持治疗3个月,随访6个月无复发。ALA-PDT是治疗儿童鲍恩样丘疹病的一种安全、有效、无明显痛苦和不良反应的新疗法。
Children with children, 9 years old. Due to the emergence of the black papules more than 1 month, gradually increased 1 week. Children vulva scattered or gathered in the distribution of black flat papules, some integration into plaques. Histopathological examination of the vulva lesions showed hyperkeratosis, thickening of the stratum spinosum, widening of the epidermis, and disorganization of the cell structure. The atypical cells were seen in all layers but the basilar membrane was intact. Skin lesions immunohistochemistry results showed that human papillomavirus (HPV) positive. PCR-reverse dot hybridization test results HPV-16 (high-risk type) positive. According to clinical and laboratory tests confirmed by HPV-16 infection caused Bowen-like papulosis. Given 5-aminolevulinic acid (ALA) photodynamic therapy (PDT) treatment 3 times, vulva lesions all subsided. After external imiquimod ointment maintenance treatment for 3 months, followed up for 6 months without recurrence. ALA-PDT is a new treatment for children with Bowenoid disease that is safe, effective, and has no apparent pain or adverse reactions.