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目的 :研究胃肠宁治疗溃疡性结肠炎的作用机理。方法 :对大鼠溃疡性结肠炎 (UC)模型胃肠激素SP、VIP含量、血液流变学、免疫功能、消炎、镇痛作用进行观察。结果 :治疗组SP、VIP较模型组明显降低 ;血液流变学指标全血粘度、纤维蛋白粘度、红细胞压积测定 ,治疗组较模型组降低 ;能明显抑制小鼠耳廓肿胀和大鼠关节肿胀 ;提高小鼠痛阈百分率 ;提高小鼠腹腔巨噬细胞的吞噬指数和吞噬率 ;对外周免疫器官脾脏有明显影响。结论 :胃肠宁具有抗炎、镇痛、改善微循环 ,调节胃肠激素、植物神经及免疫功能等作用。
Objective: To study the mechanism of action of Weiening on ulcerative colitis. Methods: The gastrointestinal hormones SP, VIP content, hemorrheology, immune function, anti-inflammatory and analgesic effects of ulcerative colitis in rats were observed. Results: The levels of SP and VIP in the treatment group were significantly lower than those in the untreated group. The indexes of hemorheology, such as whole blood viscosity, fibrin viscosity and hematocrit, were lower in the treatment group than those in the untreated group. Swelling, increasing the percentage of pain threshold in mice, increasing the phagocytic index and phagocytosis rate of mouse peritoneal macrophages, and obviously affecting the spleen of peripheral immune organs. Conclusion: Weining Ning anti-inflammatory, analgesic, improve microcirculation, regulate gastrointestinal hormones, autonomic and immune function and so on.