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目的观察替比夫定联合补肾解毒方治疗肝胆湿热型慢性乙型肝炎的临床疗效。方法将60例患者随机分为两组。治疗组30例给予替比夫定联合补肾解毒方治疗,对照组30例单用替比夫定治疗。治疗第4周、12周、24周、48周后分别观察谷丙转氨酶(ALT)复常率、HBV-DNA转阴率、HBeAg血清学转换率。结果治疗组治疗第12周ALT复常率优于对照组(P<0.05);两组在治疗第48周的HBV-DNA阴转率和HBeAg血清学转换率比较,差异有统计学意义(P<0.05)。结论替比夫定联合补肾解毒方能明显改善肝功能,并有一定抗乙型肝炎病毒的作用,疗效肯定。
Objective To observe the clinical efficacy of telbivudine combined with Bushen Jiedu Fang in treating chronic hepatitis B with hepatobiliary and damp-heat syndrome. Methods Sixty patients were randomly divided into two groups. In the treatment group, 30 patients were treated with telbivudine combined with Bushen Jiedu decoction and the control group, 30 patients were treated with telbivudine alone. At week 4, week 12, week 24, and week 48, ALT normalization rate, HBV-DNA negative rate and HBeAg seroconversion rate were observed. Results The ALT recovery rate was higher in the treatment group than in the control group at 12 weeks (P <0.05). There was significant difference in the HBV-DNA negative conversion rate and HBeAg seroconversion rate between the two groups <0.05). Conclusion Telbivudine combined with kidney detoxification can significantly improve liver function, and some anti-hepatitis B virus effect, the effect is sure.