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目的:研究非哺乳期乳腺炎患者细菌感染和免疫指标的相关性。方法:采用随机数字表法选择2019年8月至2021年8月海南省妇女儿童医学中心收治的100例非哺乳期乳腺炎患者为观察组，另随机选取同期在海南省妇女儿童医学中心进行体检的健康女性100例作为对照组。观察组年龄（35.29±4.61）岁，体质量（52.35±3.30）kg，对照组年龄（35.22±4.56）岁，体质量（52.22±3.20）kg。比较两组外周血免疫指标水平，并进行相关性分析。此外，采集所有观察组患者的脓液标本实施细菌培养以及药敏试验，分析金黄色葡萄球菌对常见抗菌药物的耐药性。结果采用n χ2检验、n t检验。n 结果:观察组外周血免疫球蛋白（Ig）A、IgM水平分别为（2.68±1.04）g/L和（1.80±0.77）g/L，均显著高于对照组［分别为（2.08±0.86）g/L、（1.28±0.46）g/L］，差异有统计学意义（n t=4.446、5.797，均n P<0.001）。经Pearson相关性分析：非哺乳期乳腺炎患者细菌感染和IgA、IgM均呈正相关关系（n r=0.574、0.611，均n P<0.05）。非哺乳期乳腺炎患者脓液标本主要病原菌为金黄色葡萄球菌，占73.00%（73/100）。金黄色葡萄球菌对常见抗菌药物的耐药性按照从高到低的顺序依次为青霉素（87.67%，64/73）、苯唑西林（75.34%，55/73）、克林霉素（38.36%，28/73）、庆大霉素（27.40%，20/73）、呋喃妥因（10.96%，8/73）、左氧氟沙星（9.59%，7/73）、四环素（8.22%，6/73）、万古霉素（0）。n 结论:非哺乳期乳腺炎患者细菌感染和免疫指标存在密切相关，且其主要病原菌为金黄色葡萄球菌，对万古霉素具有较高的敏感性。“,”Objective:To study the correlation between bacterial infection and immune index in non-lactation mastitis patients.Methods:One hundred patients with non-lactating mastitis treated at Hainan Women and Children\'s Medical Center from August 2019 to August 2021 were randomly selected as an observation group, and another 100 healthy women who had physical examination at Hainan Women and Children\'s Medical Center during the same time were randomly selected as a control group. The observation group was (35.29±4.61) years old, and their body weight was (52.35±3.30) kg. The control group was (35.22±4.56) years old, and their body weight was (52.22±3.20) kg. The levels of peripheral blood immune indicators in the two groups were compared, and the correlation was analyzed. The pus samples were collected from the patients in the observation group for bacterial culture and drug susceptibility test, and the resistance of staphylococcus aureus to common antibiotics was analyzed. n χ2 and n t tests were applied.n Results:The levels of immunoglobulin (Ig) A and IgM in the peripheral blood were (2.68±1.04) g/L and (1.80±0.77) g/L in the observation group, and were (2.08±0.86) g/L and (1.28±0.46) g/L in the control group, with statistical differences (n t=4.446 and 5.797; both n P<0.001). Pearson correlation analysis showed that the bacterial infection in the patients with non-lactation mastitis was positively correlated with IgA and IgM (n r=0.574 and 0.611, bothn P<0.05). Staphylococcus aureus was the main pathogen in the pus samples, accounting for 73.00% (73/100). The drug resistance rates of staphylococcus aureus to penicillin, benzoxicillin, clindamycin, gentamycin, furantoin, levofloxacin, tetracycline, and vancomycin were 87.67% (64/73),75.34% (55/73),38.36% (28/73),27.40% (20/73),10.96% (8/73),9.59% (7/73),8.22% (6/73), and 0.n Conclusion:There is a close relationship between bacterial infection and immune indicators in patients with non-lactating mastitis, and the main pathogen is Staphylococcus aureus, which has a high sensitivity to vancomycin